منابع مشابه
IL-6-induced skeletal muscle atrophy.
Chronic, low-level elevation of circulating interleukin (IL)-6 is observed in disease states as well as in many outwardly healthy elderly individuals. Increased plasma IL-6 is also observed after intense, prolonged exercise. In the context of skeletal muscle, IL-6 has variously been reported to regulate carbohydrate and lipid metabolism, increase satellite cell proliferation, or cause muscle wa...
متن کاملRole of IL-15 in Sepsis-Induced Skeletal Muscle Atrophy and Proteolysis
BACKGROUND Muscle wasting in sepsis is associated with increased proteolysis. Interleukin-15 (IL-15) has been characterized as an anabolic factor for skeletal muscles. Our study aims to investigate the role of IL-15 in sepsis-induced muscle atrophy and proteolysis. METHODS Mice were rendered septic either by cecal ligation and puncture or by intraperitoneal injection of lipopolysaccharide (LP...
متن کاملInhibition of interleukin-6 decreases atrogene expression and ameliorates tail suspension-induced skeletal muscle atrophy
BACKGROUND Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. METHODS Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrog...
متن کاملDeletion of Nlrp3 protects from inflammation-induced skeletal muscle atrophy
BACKGROUND Critically ill patients develop atrophic muscle failure, which increases morbidity and mortality. Interleukin-1β (IL-1β) is activated early in sepsis. Whether IL-1β acts directly on muscle cells and whether its inhibition prevents atrophy is unknown. We aimed to investigate if IL-1β activation via the Nlrp3 inflammasome is involved in inflammation-induced atrophy. METHODS We perfor...
متن کاملExtracellular Matrix and Gelatinases in Disuse-induced Skeletal Muscle Atrophy
+Liu, X.; Lee, D., Natsuhara K., Kim, H. +University of California, San Francisco, CA, Veterans Affairs Medical Center, San Francisco, CA Senior author: [email protected] INTRODUCTION: Extracellular matrix (ECM) plays a critical role in maintaining normal structure and function of skeletal muscle. Muscle basement membrane serves as an interface between cells and the rest of matrix. It is ...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2005
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.01026.2004